RISKI ANGGRAENI, NIM. C12019024 (2023) UJI EFEK ANTIDIARE EKSTRAK METANOL DAN EKSTRAK AKUADES DAUN MENGKUDU (Morinda citrifolia L.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR DENGAN METODE INDUKSI OLEUM RICINI. Skripsi thesis, UNIVERSITAS MUHAMMADIYAH GOMBONG.
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Abstract
Background: Diarrhea is a disease characterized by changes in stool consistency and an increase in the frequency of bowel movements three or more times a day. The use of antidiarrheal drugs such as Imodium causes side effects such as stomach pain, nausea or vomiting, so an alternative treatment for diarrhea is needed using natural ingredients, one of which is noni leaf (Morinda citrifolia L.). Objective: The aim of the study was to determine the antidiarrheal effect and the effective dose of methanol extract and noni leaf distilled water (Morinda citrifolia L.) in reducing diarrhea seen from the test parameters. Methods: This research was a laboratory experiment using methanol extract and distilled water extract of noni leaves with 40 mice as subjects. The test animals were divided into 8 treatment groups, namely the negative control (CMC-Na 0.5%), the positive control (Imodium), the methanol extract group at doses of 300, 450 and 600 mg/kgBW, and the aquadest extract group at doses of 300, 450 and 600 mg/kgBB. Test animals induced with castor oil. Parameters observed included defecation frequency, defecation consistency, and stool weight Result: Methanol extract and distilled water extract had antidiarrheal effect on induced male white rats castor oil seen from the observation that at a dose of 300 mg/kgBW it can significantly reduce the frequency of defecation by 67.39% and 26.08%, as well as increase the consistency of defecation. Meanwhile, the methanol extract and distilled water extract at a dose of 600 mg/kg BW significantly reduced the weight of the stool by 112.4% and 30.18%. Conclusion: Methanol extract and distilled water extract can have an antidiarrheal effect at a dose of 300 mg/kg BW to improve frequency and consistency and 600 mg/kg BW to reduce stool weight. Recommendation: The research carried out still uses castor oil induction so that it is not optimal for anti-diarrheal tests and it is not certain that the anti-diarrheal effect is caused by tannin compounds. Further research can be done using the intestinal transit method.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | apt. Drs. Muh Husnul Khuluq, M.Farm; apt. Tri Cahyani Widiastuti, M.Sc |
| Uncontrolled Keywords: | antidiarrheal; noni leaves (Morinda citrifolia L.); castor oil; antidiare; daun mengkudu (Morinda citrifolia L.); oleum ricini |
| Subjects: | S1 Farmasi |
| Divisions: | Prodi Farmasi S1 |
| Depositing User: | Unnamed user with email stikesmuhgombong@yahoo.com |
| Date Deposited: | 06 Dec 2023 03:57 |
| Last Modified: | 06 Dec 2023 03:57 |
| URI: | http://repository.unimugo.ac.id/id/eprint/2999 |
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