UJI AKTIVITAS ANTIINFLAMASI EKSTRAK AKUADES DAUN MELINJO (Gnetum gnemon L.) PADA TIKUS PUTIH GALUR Wistar YANG DIINDUKSI KARAGENAN

YUSUF KURNIAWAN, NIM. C11700130 (2021) UJI AKTIVITAS ANTIINFLAMASI EKSTRAK AKUADES DAUN MELINJO (Gnetum gnemon L.) PADA TIKUS PUTIH GALUR Wistar YANG DIINDUKSI KARAGENAN. Skripsi thesis, UNIVERSITAS MUHAMMADIYAH GOMBONG.

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Abstract

Background, melinjo leaf (Gnetum gnemon L.) is one of the natural plants that can be used to treat of inflammation. Research purpose, the aim of this study was to find out the anti inflmmatiory activity of melinjo leaf aquadest exstract (Gnetum gnemon L.) againts carrageenan-induced white wistar rats. Methods, this study used Witer method at 25 wistar male rats which had been divided into 5 group. Group I is a positive control (diclofenac sodium) , group II as a negative control (CMC-Na), group III, IV, and V as a of extract 363, 463, and 563 mg/kgBW. Each of them were given 1 hour after carrageenan 2% induced. Edema volume of the feet of rats was measured usinga plastymometer every 15 minutes for 3 hours. Result, the results showed that the melinjo leaf (Gnetum gnemon L.) aquadest extract grup 563 mg/kgBW had a best anti-inflammatory effect because it has the highest percentage of anti-inflammatory effects and has a p < 0,05 or significantly different when compared to the positive and negative control groups. Conclusion, Based on the results of the study, the anti-inflammatory effect on the edema volume of mouse feet is 563 mg/kgBW. Recommendation, recommendations from this study are that further research needs to be done using different methods and solvents.

Item Type:	Thesis (Skripsi)
Additional Information:	Apt. Drs. Muh. Husnul Khuluq, M.Farm; Apt. Titi Pudji Rahayu, M.Farm
Uncontrolled Keywords:	Melinjo leaf (Gnetum gnemon L.), anti-inflammatory, diclofenac sodium, CMC-Na, carrageenan; Daun melinjo (Gnetum gnmon L.), Antiinflamasi, Natrium diklofenak, CMC-Na, Karagenan, Daun melinjo (Gnetum gnmon L.), Antiinflamasi, Natrium diklofenak, CMC-Na, Karagenan
Subjects:	S1 Farmasi
Depositing User:	DWI SUNDARIYATI S.I.Pust
Date Deposited:	31 May 2022 06:35
Last Modified:	31 May 2022 06:35
URI:	http://repository.unimugo.ac.id/id/eprint/1738

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