AGUNG KURNIAWAN, NIM. C12019002 (2023) UJI EFEK ANALGESIK EKSTRAK METANOL DAN EKSTRAK AKUADES DAUN MENGKUDU (Morinda citrifolia L.) PADA MENCIT PUTIH JANTAN (Mus musculus) GALUR SWISS WEBSTER DENGAN METODE RANGSANG KIMIA. Skripsi thesis, UNIVERSITAS MUHAMMADIYAH GOMBONG.
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Abstract
Background: Pain is an unpleasant feeling and emotional experience due to tissue damage. Noni (Morinda citrifolia L.) is a medicinal plant that has benefits in traditional medicine to help relieve and cure variety of diseases, one of which is pain. Research purposes: This study aims to determine the best analgesic activity and concentration of methanol and noni leaves (Morinda citrifolia L.) aquades extract in a male white mice (Mus musculus) induced by pain with 1% acetic acid. Research methods: This study was an experimental study with 50 male white mice as subjects. The test animals were divided into 10 treatment groups with 5 treatment groups in each extract, namely the negative control was given 1% CMC-Na, the positive control was given ponstan, the methanol extract and aquadest extract groups dosed at 150 mg/Kg BW, 300 mg/Kg BW, and 600 mg/Kg BW. The pain inducer given was 1% acetic acid. Observations were made by observing the movement of mice to calculate the % pain protection. The data obtained was then tested with One Way ANOVA and Post Hoc LSD or Games Howell statistical tests. Research results: Methanol extract and noni leaves (Morinda citrifolia L.) aquades extract in doses of 150 mg/Kg BW, 300 mg/Kg BW, and 600 mg/Kg BW have an analgesic effect on male white mice and give significant effect (p< 0.05) on mice induced by 1% acetic acid. Conclusion: Methanol extract of noni leaves (Morinda citrifolia L.) in a dosage of 600 mg/Kg BW has the best analgesic effect upon male white mice is expressed significant with a value p <0.05 and a greater positive mean difference value. Compared to the mean difference value of extracts of noni leaf aqueous extract (Morinda citrifolia L.) is smaller. Recommendation: It is necessary to carry out further research on the analgesic effect of methanol extract and aquades extract using other methods.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | apt. Drs. Muh Husnul Khuluq, M.Farm; apt. Titi Pudji Rahayu, M.Farm |
| Uncontrolled Keywords: | analgesic; noni leaves; methanol; aquades; analgetik; daun mengkudu; metanol; akuades |
| Subjects: | S1 Farmasi |
| Divisions: | Prodi Farmasi S1 |
| Depositing User: | Desy Setiyawati - |
| Date Deposited: | 15 Nov 2023 03:25 |
| Last Modified: | 15 Nov 2023 03:25 |
| URI: | http://repository.unimugo.ac.id/id/eprint/2912 |
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