IKA SETIANI, NIM. C12019020 (2023) PERBANDINGAN EFEK ANALGESIK EKSTRAK AKUADES DAN EKSTRAK ETANOL 70%DAUN BELIMBING WULUH (Averrhoa bilimbi L.) TERHADAP MENCIT PUTIH JANTAN (Mus musculus) GALUR SWISS WEBSTER DENGAN METODE INDUKSI ASAM ASETAT 1%. Skripsi thesis, UNIVERSITAS MUHAMMADIYAH GOMBONG.
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Abstract
Background: Pain is an emotional and sensory experience associated with tissue damage. Pain medication has side effects, so need for alternatives using natural ingredients. One of them is wuluh star fruit leaves which contain flavonoids as analgesics. Research Objective: To knowing the comparison of the analgesic effect of aqueous extract and ethanol 70% extract of wuluh star fruit leaves against male white mice with acetic acid 1% induction. Research Method: Is an experimental study using 40 male white mice divided into 8 treatment groups. The control group was negative (CMC Na 1%), the positive control group (Ponstan), and the aqueous and ethanol 70% extract group at doses of 200, 400, and 600 mg/kgBW. The pain inducer is acetic acid 1%. Observations were made by observing the tickle of mice to calculate the % squirrel protection. The data obtained was then statistically tested with One Way ANOVA. Results of the study: The results showed that aqueous and ethanol 70% extracts of wuluh star fruit leaves at doses of 200, 400, and 600 mg/kgBW had an analgesic effect on mice. The most effective dose in both extracts was a dose of 400 mg/kgBW with % protection value of 78.62% and 85.40% respectively. Ethanol 70% extract dose 400 mg/kgBW has the best analgesic effect compared to aqueous extract as evidenced by a greater % protection value of 85.40% with a significance value of p<0.05 (p = 0.000). Conclusion: Ethanol 70% extract at dose 400 mg/kgBW has the best analgesic effect than aqueous extract with a greater % protection value and is expressed significantly with a value of p<0.05 (p = 0.000). Recommendation: For further research, it is recommended to use other analgesic test methods, such as the hot plate method, tail flick method, electrical induction method and mechanical method.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | apt. Dr. Muh. Husnul Khuluq, M.Farm;apt. Tri Cahyani Widiastuti, M.Sc |
| Uncontrolled Keywords: | Wuluh star fruit leaves (Averrhoa bilimbi L.), analgesics, flavonoids;Daun belimbing wuluh (Averrhoa bilimbi L.), analgesik, flavonoid. |
| Subjects: | S1 Farmasi |
| Depositing User: | Unnamed user with email [email protected] |
| Date Deposited: | 25 Nov 2023 04:21 |
| Last Modified: | 25 Nov 2023 04:21 |
| URI: | http://repository.unimugo.ac.id/id/eprint/2955 |
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