BERNA DITA MAESTRI, NIM. C12020005 (2024) STUDI INSILICOPOTENSI SENYAWA BUNGA KENANGA (Cananga odorata) SEBAGAI KANDIDAT ANTIVIRUS HEPATITIS B (HBV). Skripsi thesis, UNIVERSITAS MUHAMMADIYAH GOMBONG.
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Abstract
Background: Hepatitis, caused by liver inflammation from hepatotropic viruses, is a significant global health concern. In Indonesia, Hepatitis B prevalence was 7.1% (18 million cases) in 2013, increasing to 7.5% by 2018. Tenofovir, the primary Hepatitis B therapy, poses risks such as renal failure, medication nonadherence, and an 8.8% resistance rate in Indonesia. Cananga (Cananga odorata) shows potential for development as an alternative therapy for treating Hepatitis B. Purpose: This study aims to explore and identify the potential of active compounds from Cananga flower as Hepatitis B antivirals through HBXIP protein activation. Method: The research was conducted in silico using moleculer docking methods between the HBXIP receptor and test compounds alongside a comparator using Autodock software. The test compounds are secondary metabolites from Cananga that meet physicochemical, pharmacokinetic, and toxicity requirements. Tenofovir was used as the comparator. Statistical analysis was performed using ANOVA. Result: Screening of Cananga secondary metabolites identified three compounds that met the criteria: Cuparene, Beta-Caryophyllene, and Germacrene D. Docking results showed binding energy values of -5.42, -5.52, and -5.72 kcal/mol for HBXIP receptor with Cuparene, Beta-Caryophyllene, Germacrene D, and the comparator Tenofovir, respectively. Conclusion: Based on the results, the most promising secondary metabolite with potential as an anti-Hepatitis B agent is Germacrene D, which interacts by forming hydrophobic bonds. Recomendation: Further comparison using different software for docking results and subsequent in vitro and in vivo testing are recommended.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | Sugeng Supriyanto, M.S.Farm; apt. Naelaz Zukhruf W.K., M.Pharm.Sci |
| Uncontrolled Keywords: | in silico; moleculer docking; antihepatitis B; cananga odorata |
| Subjects: | S1 Farmasi |
| Divisions: | Prodi Farmasi S1 |
| Depositing User: | Unnamed user with email [email protected] |
| Date Deposited: | 19 Nov 2024 08:05 |
| Last Modified: | 05 Mar 2025 05:38 |
| URI: | http://repository.unimugo.ac.id/id/eprint/3590 |
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