UJI AKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK DAUN MANGGA ARUMMANIS (Mangifera indica L.) DAN KUNIR PUTIH (Curcuma mangga Val.) TERHADAP KADAR GLUKOSA DARAH TIKUS JANTAN GALUR WISTAR YANG DIINDUKSI STREPTOZOTOCIN

SINTA SUPARNINGSIH, NIM. C12020044 (2024) UJI AKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK DAUN MANGGA ARUMMANIS (Mangifera indica L.) DAN KUNIR PUTIH (Curcuma mangga Val.) TERHADAP KADAR GLUKOSA DARAH TIKUS JANTAN GALUR WISTAR YANG DIINDUKSI STREPTOZOTOCIN. Skripsi thesis, UNIVERSITAS MUHAMMADIYAH GOMBONG.

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Abstract

Background: Diabetes mellitus requires long-term treatment, side effects and presumption of medication lead to decreased treatment adherence. Alternatives such as herbs are needed because they have few side effects. Mango Arummanis and White Turmeric Leaves are herbs with flavonoids, tannins and curcumin that have the potential to be antidiabetic agents. Objective: To determine the effect and effective dosage of the combination of Mango Arummanis Leaf extract and White Turmeric as an antidiabetic Research Method: An experimental (in-vivo) study with treatment groups (normal control, negative control, positive control, and a combination group of P, Q and R extracts with a dose comparison of Arummanis Mango Leaf Extract: White Turmeric 210:210, 250:170 and 170:250 mg/kgBB respectively). The percentage of decrease in blood glucose levels and weight gain was analyzed by the SPSS Version 25 statistical test. Research Results: The three combinations of extracts on the percentage of decrease in glucose levels (P value > 0.05) and the percentage of change in body weight (P value <0.05). The P extract group showed the best reduction (48%) Conclusion: The three combinations of extracts did not show significant differences. The P extract group at a dose of 210:210 mg/kgBB showed the best reduction in blood glucose levels, comparable to glimepiride. All three combinations of extracts showed weight gain. Recommendation: It is necessary to carry out follow-up toxicity tests and weight change mechanisms.

Item Type: Thesis (Skripsi)
Additional Information: apt. Laeli Fitriyati, M.Farm; apt. Titi Pudji Rahayu, M.Farm
Uncontrolled Keywords: antidiabetic; arummanis; white turmeric; herbs; streptozotocin; antidiabetes; Arummanis; kunir putih; herbal
Subjects: S1 Farmasi
Divisions: Prodi Farmasi S1
Depositing User: Unnamed user with email lib.unimugo@gmail.com
Date Deposited: 30 May 2025 03:48
Last Modified: 30 May 2025 03:48
URI: http://repository.unimugo.ac.id/id/eprint/3808

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