SYAFRIZAL DIAN HIDAYATULLOH, NIM. C12020047 (2024) AKTIVITAS ANTIDIABETES INFUSA KUNYIT HITAM (Curcuma caesia Roxb) PADA TIKUS JANTAN GALUR WISTAR (Rattus norvegicus) YANG DIINDUKSI STREPTOZOTOCIN. Skripsi thesis, UNIVERSITAS MUHAMMADIYAH GOMBONG.
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Abstract
Background: Diabetes mellitus is a metabolic disorder characterized by decreased insulin production by the pancreas. In Indonesia, the prevalence of diabetes was 6.2% in 2020, and this number is expected to rise by 2045. Black turmeric is one of the natural substances that can be used as an alternative treatment for diabetes. Objective: To determine the activity and optimal dose of black turmeric rhizome infusion as an antidiabetic treatment in streptozotocin-induced rats. Method: This laboratory experimental study used black turmeric rhizome infusion on 24 male Wistar rats. The rats were divided into 6 treatment groups: normal control, positive control, negative control, and groups receiving black turmeric rhizome infusion at doses of 5%, 10%, and 15%. The study employed a diabetes model induced with streptozotocin at 45 mg/kg body weight via intraperitoneal injection. Treatment was administered orally for 21 days, with blood glucose levels measured on days 7, 14, and 21 using a glucometer. Blood glucose reduction was calculated using the percentage reduction formula and analyzed with SPSS version 25. Results: SPSS analysis showed average reductions of -53.250 for the 5% infusion, -66.000 for the 10% infusion, and -75.500 for the 15% infusion. The p-values were 0.083, 0.049, and 0.030, respectively. Conclusion: Black turmeric rhizome has antidiabetic effects, with the most effective dose being 15%. Recommendation: Further research is needed on in vitro antidiabetic testing and toxicity evaluation of black turmeric rhizome infusion.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | apt. Anwar Sodik, M.Farm; apt. Drs. Muh. Husnul Khuluq, M.Farm |
| Uncontrolled Keywords: | antidiabetic; black turmeric rhizome; streptozotocin; infusion; flavonoids; antidiabetes; rimpang kunyit hitam; streptozotocin; infusa; flavonoid |
| Subjects: | S1 Farmasi |
| Divisions: | Prodi Farmasi S1 |
| Depositing User: | Unnamed user with email lib.unimugo@gmail.com |
| Date Deposited: | 30 May 2025 08:00 |
| Last Modified: | 30 May 2025 08:00 |
| URI: | http://repository.unimugo.ac.id/id/eprint/3809 |
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