DINNY PUTRI ANJANI, NIM. 2021050010 (2025) PENYESUAIAN DOSIS OBAT DAN HUBUNGANNYA DENGAN OUTCOME TERAPI PADA PASIEN GAGAL GINJAL KRONIS DI INSTALASI RAWAT INAP RSUD DR. SOEDIRMAN KEBUMEN TAHUN 2024. Skripsi thesis, UNIVERSITAS MUHAMMADIYAH GOMBONG.

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Abstract

Background: In patients with chronic kidney disease (CKD), appropriate dosage adjustment is essential to avoid adverse drug effects and to ensure optimal therapeutic outcomes, thereby achieving effective treatment. Objectives: To determine the drug dosage patterns in CKD patients and their relationship with therapeutic outcomes in the inpatient unit of Dr. Soedirman Regional General Hospital Kebumen in the period 2024. Methods: This study used a descriptive-analytical design with a cross-sectional approach. Data were collected retrospectively using total sampling of 52 patients. Bivariate analysis was conducted to examine the relationship between independent and dependent variables using the chi-square test. Results: Of the 52 patients, the majority were male (27 patients, 51.92%), aged 51–59 years (24 patients, 46.15%), in stage 4 CKD (42 patients, 80.76%), and had anemia as a comorbidity (22 patients, 30.77%). A total of 133 drugs required dose adjustment, with 104 prescriptions (78%) properly adjusted, while 29 prescriptions (22%) were not adjusted. Therapeutic outcomes improved in 28 patients (53.84%), while 24 patients (46.15%) showed no improvement. The analysis of the relationship between dosage adjustment and therapeutic outcomes showed a significant correlation, with a p-value of 0.015, indicating that H0 was rejected and H1 was accepted. Conclusion: Drug dosage adjustment has a significant relationship with improved therapeutic outcomes in patients with chronic kidney disease, with 28 patients (53.84%) experiencing improvement. Recommendation: Further research is recommended to use prospective methods for more comprehensive results.

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