ANINDYA ARYA PAMUNGKAS, NIM. C11800139 (2024) Uji Aktivitas Antibakteri Sediaan Krim Ekstrak N Heksan Daun Pepaya (Carica papaya L) Terhadap Bakteri Propionibacterium acnes. Skripsi thesis, UNIVERSITAS MUHAMMADIYAH GOMBONG.
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Abstract
Background, Acne is a widely known disease that often appear on the face. The arises of acne will be less attractive appearance and beauty of a person. One of the bacteria that cause acne is Propionibacterium acnes. Papaya leaves have active compounds that can potentially act as anti-acne agents. Research Objective, This study aims to determine the antibacterial cream preparation of n hexanes extract of Papaya Leaf (Carica papaya L) can be used to inhibit the growth of Propionibacterium acnes bacteria. Methods, This study used papaya leaves which were macerated using n hexanes. The n hexanes extract of papaya leaves was made into cream preparations with concentration variations of 5%, 7.5% and 10%. The cream evaluation test includes organoleptical test, homogeneity test, pH test, spreadability test, adhesion test, viscosity test, cream type test, and stability test. The cream was carried out antibacterial test with the well method. The data obtained were tested using One Way ANOVA. Result, The results of the cream preparation test met the physical quality requirements of the preparation includes organoleptical test, homogeneity test, pH test, spreadability test, adhesion test, viscosity test, cream type test, and stability test. Antibacterial test showed that the three formulations had moderate inhibitory power against Propionibacterium acnes bacteria. The average measurement of inhibitory zone in formula 1, formula 2, formula 3 is 7.95 ± 0.68 mm, 7.8 ± 0.64 mm, and 8 ± 0.76 mm, respectively. The antibacterial activity of all formulations did not have a significant difference because p>0.05. Conclusion, The results of 3 formulations met the physical quality requirements of the preparation includes organoleptical test, homogeneity test, pH test, spreadability test, adhesion test, viscosity test, cream type test, and stability test. All cream formulations of n hexanes extract of papaya leaves had moderate inhibitory power against Propionibacterium acnes bacteria. The antibacterial activity of all formulations did not have a significant difference because p>0,05. Recommendation, It is necessary to do further research using n hexanes extract of papaya leaves into various other pharmaceutical preparations and test antibacterial activity using different methods against other bacteria.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | apt. Naelaz Zukhruf W.K., M.Pharm., Sci;apt. Titi Pudji Rahayu.,M.Farm |
| Uncontrolled Keywords: | Papaya Leaf; N hexanes; Propionibacterium acnes; Antibacterial; Cream.;Daun pepaya; N heksan; Propionibacterium acnes; Antibakteri; Krim |
| Subjects: | S1 Farmasi |
| Divisions: | Prodi Farmasi S1 |
| Depositing User: | Unnamed user with email stikesmuhgombong@yahoo.com1 |
| Date Deposited: | 31 Oct 2024 03:43 |
| Last Modified: | 31 Oct 2024 03:43 |
| URI: | http://repository.unimugo.ac.id/id/eprint/3545 |
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