MELANI DHIA HUWAIDA, NIM. C2021050029 (2025) ANALISIS PENGGUNAAN ANTIBIOTIK PADA PASIEN BEDAH RAWAT INAP DENGAN MENGGUNAKAN METODE DEFINED DAILY DOSE DAN DRUG UTILIZATION 90% DI RSUD PREMBUN TAHUN 2024. Skripsi thesis, UNIVERSITAS MUHAMMADIYAH GOMBONG.

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Abstract

Background : The use of antibiotics in general surgical patients after surgery is used to prevent postoperative wound infections. The Antimicrobial Resistance in Indonesia (AMRIN) study showed that 42% of antibiotic use was indicated as inappropriate and inappropriate in surgical patients. However, the use of antibiotics that are not appropriate or excessive can cause resistance. Therefore, the use of antibiotics in surgical patients needs to be evaluated. The World Health Organization (WHO) and the Ministry of Health of the Republic of Indonesia recommend the implementation of quantitative antibiotic use using the ATC/DDD and DU 90% methods to assess the quantity of antibiotic use as an antimicrobial resistance control program (PPRA) in surgical patients at Prembun Hospital. Research Objective : Knowing the use of antibiotics in surgical patient at Prembun Hospital with the ATC/DDD and DU 90% method in period of Januari-December 2024. Research Method : In this study, the type of method used was a non-experimental method with retrospective data collection. Data on antibiotic use in postoperative patients were analyzed using the ATC/DDD and DU 90% methods. The sampling method used the Slovin formula using data that fell into the inclusion and exclusion criteria that had been determined by researchers at Prembun Hospital. Results : In this study, antibiotics for postoperative patients used at Prembun Regional Hospital were Ceftriaxone inj 1g, meropenem 1g, and ampicillin sulbactam 1.5g. The highest antibiotic was ceftriaxone inj 1g with a total of 42.80 DDD/100 patient-days and the lowest antibiotic was ampicillin sulbactam 1.5g with a total of 8.65 DDD/100 patient-days. The use of antibiotics that fell into the 90% segment was Ceftriaxone inj 1g (70.04%), meropenem inj 1g (17.10%). While antibiotics that fell into the 10% segment were ampicillin sulbactam 1.5g (14.15%). The total of all antibiotics used was 61.10 DDD/100 patient-days. Conclusion : The total antibiotics used were 61.10 DDD/100 patient-days, which means that antibiotic use at Prembun Regional Hospital is quite high. The high DDD value reflects the need for routine evaluation of antibiotic use to ensure the effectiveness of therapy and prevent potential antibiotic resistance in the future. These results can be interpreted that out of every 100 surgical patients hospitalized at Prembun Regional Hospital, 61 patients received antibiotic therapy in accordance with the World Health Organization (WHO) standard DDD value. Recommendations : Further research needed regarding the qualitative evaluation of antibiotic use using the Gyssens methode, relaated to the accuracy of antibitotic therapy, in order to assess the rationality of prescribing or drug use for eac patient.

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