AMINA FABANYO, NIM. 202413045 (2026) EVALUASI KUALITATIF DAN KUANTITATIF PENGGUNAAN ANTIBIOTIK PENYAKIT APENDISITIS DI RSUD dr. GOETENG TAROENADIBRATA PURBALINGGA PERIODE BULAN OKTOBER 2025. Professional Project Practice thesis, UNIVERSITAS MUHAMMADIYAH GOMBONG.

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Abstract

Background, Appendicitis is an intra-abdominal infection requiring appropriate antibiotic therapy to prevent complications and antimicrobial resistance. Irrational antibiotic use increases the risk of resistance and worsens clinical outcomes. Objective, This study aimed to evaluate antibiotic use in appendicitis inpatients at RSUD dr. Goeteng Taroenadibrata Purbalingga using qualitative (Gyssens method) and quantitative (Defined Daily Dose/DDD) approaches. Methods, A descriptive non-experimental study was conducted retrospectively using medical records of appendicitis patients from March–September 2025. Quantitative analysis was performed using the DDD method, while qualitative evaluation applied the Gyssens method. Results, Ceftriaxone (49.00 DDD) and metronidazole (46.87 DDD) were the most frequently used antibiotics. Qualitative evaluation revealed that 43.14% of antibiotic use was rational, while 56.86% was irrational, with the largest issue in category IVA (suboptimal antibiotic selection). Conclusion, The rationality of antibiotic use in appendicitis cases at RSUD dr. Goeteng Taroenadibrata remains suboptimal. Strengthening guideline adherence and antimicrobial stewardship programs is necessary.

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