FUAN MAHARANI FIANA, NIM. C11600022 (2020) UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN SUKUN (Artocarpus altilis) TERHADAP BAKTERI Staphylococcus aureus DAN Escherichia coli. Masters thesis, STIKES MUHAMMADIYAH GOMBONG.
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Abstract
Antibacterial Activity of Ethanol Extract of Breadfruit Leaf (Artocarpus altilis) Against Staphylococcus aureus Bacteria And Escherichia coli” Diarrhea is caused by bacterial infections, especially Staphylococcus aureus and Escherichia coli. The breadfruit leaves (Artocarpus altilis) are known contain flavonoid compounds, alkaloids, saponins, and tannins which can be used as antibacterial. This research was conducted to determine the ethanol extract of the breadfruit leaves against Staphylococcus aureus and Escherichia coli bacteria. The manufacture of the breadfruit leaf extract was using a maceration method with 96% ethanol solvent. The result of the tube test and the TLC test was positive, the breadfruit leaf extract containing flavonoids and tannins which have potential as antibacterial. The antibacterial test was carried out using the disc diffusion method (Kirby-Bauer test) against Staphylococcus aureus and Escherichia coli bacteria incubated for 1 x 24 hours. The extract concentrations tested were 10, 15 and 20%. The positive control was using erythromycin antibiotics and the negative control was using aquades. The identification of the chemical content of plants is done by tube test and the TLC test. The results of incubation of the breadfruit leaf extract with concentrations of 10, 15 and 20% against Staphylococcus aureus bacteria, the average diameter of inhibitory zones respectively were 3.67, 3.50 and 2.67 mm with the positive control diameter of inhibition zone was 18.5 mm, the negative control diameter of inhibition zone was 0 mm. The results of incubation of the breadfruit leaf extract with concentrations of 10, 15 and 20% against Escherichia coli bacteria, the average diameter of inhibitory zones respectively were 5.33, 3.17 and 3.33 mm with the positive control inhibition zone diameter of 28.5 mm and the negative control of inhibition zone diameter of 0 mmKey word: breadfruit leaf ethanol extract, antibacterial, diameter of inhibitor zone, Staphylococcus aureus, Escherichia coli. Kruskal-Wallis test on Staphylococcus aureus bacteria did not have a significant difference between the treatment with inhibition zone diameter because p> 0.05, whereas for Escherichia coli bacteria the value of p <0.05 meant that there was a significant difference between the treatment with inhibition zone diameter.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Apt. Naelaz Zukhruf W.K, M. Pharm.Sci; Apt. Titi Puji Rahayu, M.Farm |
| Uncontrolled Keywords: | The breadfruit leaves, Artocarpus altilis, Antibacterial, Staphylococcus aureus, Escherichia coli.; Daun sukun, Artocarpus altilis, Antibakteri, Staphylococcus aureus, Escherichia coli. |
| Subjects: | S1 Farmasi |
| Depositing User: | DWI SUNDARIYATI S.I.Pust |
| Date Deposited: | 11 Nov 2021 03:49 |
| Last Modified: | 11 Nov 2021 03:49 |
| URI: | http://repository.unimugo.ac.id/id/eprint/1493 |
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