LYVIA PUTRI PANGESTU, NIM. C12020030 (2024) UJI EFEK ANALGESIK EKSTRAK ETANOL KUNYIT HITAM (Curcuma caesia Roxb.) PADA TIKUS PUTIH GALUR WISTAR JANTAN (Rattus norvegicus) DENGAN METODE HOT PLATE. Skripsi thesis, UNIVERSITAS MUHAMMADIYAH GOMBONG.
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Abstract
Background: Synthetic analgesic drugs have some side effects such as serious gastrointestinal problems. Herbal remedies have relatively few side effects. Black turmeric rhizomes contain flavonoid compounds, alkaloids, and tannins that have the potential to be natural analgesics. Objective: To determine the analgesic activity of black turmeric ethanol extract (Curcuma caesia Roxb.) on white rats of male wistar strain (Rattus norvegicus) by hot plate method. Method: Black turmeric was extracted using the maceration method with a 70% ethanol solvent. The extract was carried out standardization test, tube test and KLT test. It is using the research subject in the form of 25 white rats. The test animals were divided into 5 treatment groups, namely negative control (CMC Na), positive control (mefenamic acid), black turmeric ethanol extract (Curcuma caesia Roxb.) at doses of 100, 200 and 400 mg/kgBB. The method used is hot plate. Observations were made by observing the response of the rats in the form of jumping actions to calculate the percentage of pain protection. The data obtained were then tested with One Way Anova and Post Hoc LSD statistics. Results: The black turmeric extract that has been standardized has met the extract standardization and in the phytochemical screening test the extract contains flavonoid compounds, alkaloids and tannins. The analgesic effect test with the hot plate method obtained the results of black turmeric ethanol extract at doses of 100, 200 and 400 mg/kgBB had an analgesic effect with a pain protection percent parameter. Based on the data on the number of jumps in rat responses, it was found that there was no significant difference (p>0.05) between the doses of black turmeric extract. Conclusion: Black turmeric extract at a dose of 400 mg/kgBB provides the best analgesic effect showing a percent value of protection against pain, which is 82.72%. Suggestion: It is necessary to conduct toxicity tests or other activity tests, formulations using black turmeric plants (Curcuma caesia Roxb.).
| Item Type: | Thesis (Skripsi) |
|---|---|
| Additional Information: | apt. Anwar Sodik, M.Farm.;apt. Drs. Muh Husnul Khuluq, M.Farm |
| Uncontrolled Keywords: | Analgesic, black turmeric, ethanol, rats, hot plate;Analgesik, kunyit hitam, etanol, tikus, hot plate |
| Subjects: | S1 Farmasi |
| Depositing User: | Unnamed user with email [email protected] |
| Date Deposited: | 06 Nov 2024 01:49 |
| Last Modified: | 06 Nov 2024 01:49 |
| URI: | http://repository.unimugo.ac.id/id/eprint/3554 |
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